White Kwao Krua Tablets In Pakistan
White Kwao Krua Tablets in Pakistan and Dubai In Pakistan 1 The increase of plasma low-density lipoprotein (LDL) from the diet passes through the endothelial barrier and deposits on the arterial wall, plays a crucial role in atherosclerosis development. The accumulation of LDL transforms into oxidized-LDL (oxLDL) and constitutes the hallmark of the disease. The presence of oxLDL not only produces self-reactive oxygen species (ROS) but also activates endothelial cells to release more ROS and pro-inflammatory cytokines.2 This increases the leukocyte migration, subendothelial space retention,3 leukocyte adhesion to the vascular endothelial cells,4 and even synergizes the effect of air-pollutant-induced vascular inflammation.5Besides,
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it led to the improvement of vascular function by recovering endothelium-dependent relaxation and alleviating vascular structure impairment induced by high-fat dietary intake. Several previous studies demonstrated that dyslipidemia, oxidation, and inflammation related to the pathogenesis of atherosclerosis.White kwao krua is an edible plant that grows in Southeast Asia.
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It is very rich in natural phytoestrogens. Previous clinical studies revealed that the use of White kwao krua as a hormone replacement therapy has beneficial effects on the lipid profile of menopausal women. In this present study, we utilized the hypercholesterolemia rabbit model to demonstrate the effect of White kwao krua on the daily intake of a high-fat diet.We induced hypercholesterolemia in rabbits by feeding with high-fat diet (1% cholesterol-containing diet).
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